Atrium: ClearWay RX

Click on the camera to compare ClearWay™ RX to traditional intracoronary delivery in this angiogram video.

.014" Guidewire
6&7 Fr Guide Catheter
4&5 Fr Introducer Sheath
1-4 ATM Infusion Pressure
134cm Catheter Working Length
Additional Balloon Lengths Pending
World's First Rapid Exchange OCI Catheter Platform Suitable for Coronary and Peripheral Applications

ClearWay™ RX is the name for a brand new atraumatic delivery methodology to enhance localized drug bioavailability and uptake with minimal dilution to general systemic circulation. This is accomplished by an extraordinarily thin, microporous PTFE balloon which controllably engages the vessel wall to occlude blood flow during infusion. By limiting flow during infusion, drug concentration to the targeted location can increase upwards of 100X or more over regular IV infusion¹. This procedure is referred to as OCI therapeutics (Occlusion, Containment, Infusion).

Localized infusion of a therapeutic agent offers several treatment options which cannot always be safely achieved with standard systemic doses or non-occluding catheter delivery methods. ClearWay’s patented atraumatic microporous balloon infuses medication at low pressure (1-4 ATM) without inducing injury to the vascular wall. ClearWay's low pressure occluding microporous balloon infuses across the entire treatment zone, maximizing the drug availability and uptake within a controlled area during infusion. OCI is a more efficient means to employ local drug delivery in a wide variety of coronary or peripheral interventions which could benefit from a more concentrated localized treatment effect.

ClearWay’s OCI therapeutic platform combines 3 procedures in 1 with Occlusion, Containment and Infusion. OCI delivery allows for a prescribed amount of drug to be infused directly into a targeted area for a desired therapeutic effect. During inflation, drug is controllably infused through the microporous balloon pores while blood flow is occluded, maximizing drug availability and residence time without substantial dilution or loss of medication to systemic circulation. Non-occluding local delivery methods result in the immediate release of drugs into the general systemic circulation, often into the aorta and into other non-targeted vessel locations.

OCI catheter delivery provides extended residence time unlike any other delivery method, maximizing drug bioavailability, concentration and dose for a desired therapeutic effect. Localized drug administration with OCI provides a higher concentration for a wide variety of locally effective medications, significantly improving the therapeutic placement strategies as compared to other non-occluding catheter delivery systems or standard IV medication methods.